Gabapentin Interactions With Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Acepromazine
      • Alfentanil
      • Alprazolam
      • Amobarbital
      • Anileridine
      • Aripiprazole
      • Asenapine
      • Baclofen
      • Benperidol
      • Benzhydrocodone
      • Bromazepam
      • Buprenorphine
      • Buspirone
      • Butabarbital
      • Butorphanol
      • Calcifediol
      • Calcium Oxybate
      • Cannabidiol
      • Carbinoxamine
      • Carisoprodol
      • Carphenazine
      • Chloral Hydrate
      • Chlordiazepoxide
      • Chlorpromazine
      • Chlorzoxazone
      • Clobazam
      • Clonazepam
      • Clorazepate
      • Clozapine
      • Codeine
      • Cyclobenzaprine
      • Daridorexant
      • Dexmedetomidine
      • Diacetylmorphine
      • Diazepam
      • Dichloralphenazone
      • Difenoxin
      • Dihydrocodeine
      • Diphenhydramine
      • Diphenoxylate
      • Doxylamine
      • Droperidol
      • Enflurane
      • Esketamine
      • Estazolam
      • Eszopiclone
      • Ethchlorvynol
      • Ethopropazine
      • Ethylmorphine
      • Fentanyl
      • Flibanserin
      • Flunitrazepam
      • Fluphenazine
      • Flurazepam
      • Fluspirilene
      • Fospropofol
      • Gabapentin Enacarbil
      • Halazepam
      • Haloperidol
      • Halothane
      • Hexobarbital
      • Hydrocodone
      • Hydromorphone
      • Hydroxyzine
      • Isoflurane
      • Ketamine
      • Ketazolam
      • Ketobemidone
      • Levocetirizine
      • Levorphanol
      • Lorazepam
      • Loxapine
      • Magnesium Oxybate
      • Meclizine
      • Melperone
      • Meperidine
      • Mephobarbital
      • Meprobamate
      • Meptazinol
      • Mesoridazine
      • Metaxalone
      • Methadone
      • Methdilazine
      • Methocarbamol
      • Methohexital
      • Methotrimeprazine
      • Methylene Blue
      • Midazolam
      • Molindone
      • Moricizine
      • Morphine
      • Morphine Sulfate Liposome
      • Nalbuphine
      • Nicomorphine
      • Nitrazepam
      • Nitrous Oxide
      • Olanzapine
      • Opium
      • Opium Alkaloids
      • Orlistat
      • Orphenadrine
      • Oxazepam
      • Oxycodone
      • Oxymorphone
      • Papaveretum
      • Paregoric
      • Pentazocine
      • Pentobarbital
      • Perampanel
      • Perazine
      • Periciazine
      • Perphenazine
      • Phenobarbital
      • Pimozide
      • Piperacetazine
      • Pipotiazine
      • Piritramide
      • Potassium Oxybate
      • Prazepam
      • Pregabalin
      • Primidone
      • Prochlorperazine
      • Promazine
      • Promethazine
      • Propofol
      • Quazepam
      • Quetiapine
      • Ramelteon
      • Remifentanil
      • Remimazolam
      • Remoxipride
      • Ropeginterferon Alfa-2b-njft
      • Secobarbital
      • Sertindole
      • Sodium Oxybate
      • Sufentanil
      • Sulpiride
      • Suvorexant
      • Tapentadol
      • Temazepam
      • Thiethylperazine
      • Thiopental
      • Thiopropazate
      • Thioridazine
      • Tilidine
      • Tizanidine
      • Tolonium Chloride
      • Topiramate
      • Tramadol
      • Triazolam
      • Trifluoperazine
      • Trifluperidol
      • Triflupromazine
      • Trimeprazine
      • Zaleplon
      • Zolpidem
      • Zopiclone
      • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Ginkgo
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate

Gabapentin warnings

Gabapentin oral capsule comes with several warnings. Call your doctor if you start having more seizures or a different kind of seizure while taking this drug.

Drowsiness warning

Gabapentin can slow your thinking and motor skills and cause drowsiness and dizziness. It’s not known how long these effects last. You should not drive or use heavy machinery while taking this drug until you know how it affects you.

Depression warning

Using this drug increases your risk of suicidal thoughts and behavior. Talk to your doctor if you feel depressed or notice any changes in your mood or behavior. Also talk to your doctor if you are having thoughts of harming yourself, including suicide.

Multiorgan hypersensitivity/DRESS warning

This medication can cause multiorgan hypersensitivity. This is also known as a drug reaction with eosinophilia and systemic symptoms (DRESS). This syndrome can be life-threatening. Call your doctor right away if you have symptoms such as a rash, a fever, or swollen lymph nodes.

Allergy warning

Gabapentin can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
  • rash

Don’t take this drug again if you have ever had an allergic reaction to it before. Taking it a second time after any allergic reaction to it could be fatal (cause death).

Alcohol interaction warning

Avoid drinking alcohol while taking gabapentin. Gabapentin can cause sleepiness, and drinking alcohol can make you even more sleepy. Alcohol can also make you more likely to feel dizzy and have trouble concentrating.

Severe breathing problems warning

Severe breathing problems can occur if you take gabapentin with opioids, such as oxycodone or hydrocodone. Taking gabapentin with an opioid increases your risk for sleepiness, breathing problems, and even death. You’re at higher risk if you already have breathing problems. Get help right away if breathing problems occur

Warnings for people with certain health conditions

For people with epilepsy: Don’t stop taking gabapentin suddenly. Doing this can increase your risk of having a condition called status epilepticus. This is a medical emergency during which short or long seizures occur for 30 minutes or more.

Gabapentin can cause problems in children aged 3–12 years who have epilepsy. It raises their risk of thought problems as well as behavioral problems, such as being hyper and acting hostile or restless.

For people with kidney problems: Your body processes this drug more slowly than normal. This may cause the drug to increase to dangerous levels in your body. Talk to your doctor about whether this drug is safe for you.

Warnings for other groups

For pregnant women: The use of gabapentin has not been studied in humans during pregnancy. Research in animals has shown negative effects to the fetus when the mother takes the drug. However, animal studies don’t always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus. Call your doctor if you become pregnant while taking this drug.

If your doctor prescribes gabapentin for you while you’re pregnant, ask about the NAAED Pregnancy Registry. This registry tracks the effects of anti-seizure drugs on pregnancy. Information can be found at

For women who are breastfeeding: Gabapentin may pass into breast milk and cause serious side effects in a breastfeeding child. Tell your doctor if you are breastfeeding. You should decide together if you should stop taking this drug or stop breastfeeding.

For seniors: Kidney function may decrease with age. You may process this drug more slowly than younger people. Your doctor may start you on a lowered dose so that too much of this drug does not build up in your body. Too much of the drug in your body can be dangerous.

For children: Gabapentin has not been studied in children for the management of postherpetic neuralgia. It should not be used in people younger than 18 years. This drug should not be used to treat partial seizures in children younger than 3 years.