FAQs: Are There any Negative Side Effects of the Pain Killer Fioricet?

Fioricet is a combination medication that is used to treat complex tension headaches when other medications have not been effective.

Fioricet is a combination medication used to treat migraines or severe headaches. Learn the uses, effects and how to use Fioricet safely.

What is Fioricet?

Fioricet is the brand name multi-ingredient medication that’s used to treat some types of headaches. It’s also available in generic form.
Fioricet contains:

  • butalbital 50mg
  • acetaminophen 300mg
  • caffeine 40mg

It’s FDA-approved to treat symptoms of a common type of headache known as tension headache but is also prescribed off-label for migraine.

Butalbital APAP Caffeine is used to treat tension headaches. Acetaminophen helps to decrease the pain from the headache. Caffeine helps increase the effects of acetaminophen. Butalbital is a sedative that helps to decrease anxiety and cause sleepiness and relaxation.

Butalbital APAP Caffeine has following side effects: Bloated or “gassy” feeling, dizziness or lightheadedness (mild), drowsiness (mild), nausea, vomiting, or stomach pain (occurring without other symptoms of overdose), Bleeding or crusting sores on lips, chest pain, fever with or without chills, hive-like swellings (large) on eyelids, face, lips, and/or tongue, muscle cramps or pain

Butalbital APAP Caffeine can not be taken for a long time, your body may get used to it so that larger amounts are needed to produce the same effects. This is called tolerance to the medicine. Also, butalbital may become habit-forming (causing mental or physical dependence) when it is used for a long time or in large doses. Physical dependence may lead to withdrawal side effects when you stop taking the medicine. In patients who get headaches, the first symptom of withdrawal may be new (rebound) headaches.

Gabapentin Neurontin is a good medicine for Migraine Prevention.

Are there any negative side effects of the pain killer Fioricet?

Fioricet Side Effects
Fioricet Side Effects

the doctor prescribed Fioricet to me with regard to my migraines. My Rx says that I can take two tablets – 4 times a day. Are there any known long term side effects from using this drug? I take them pretty regularly.

Nausea, vomiting, abdominal pain, constipation, dry mouth, shaking (tremor), shortness of breath, increased urination, lightheadedness, dizziness, drowsiness, or trouble sleeping may occur.

If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes, fainting, seizures, fast/irregular heartbeat. A very serious allergic reaction to this drug is rare.

However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects.

If you notice other effects not listed above, contact your doctor or pharmacist. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

18 responses to “FAQs: Are There any Negative Side Effects of the Pain Killer Fioricet?”

  1. Not really, Fioricet is a weakend version of percocet, the main side-effect is dependance on the drug, however if you develop a fever that lasts for more than 3 days discontinue and see a doctor.

  2. Reported side effects include drowsiness, dizziness, confusion or lightheadedness, shortness of breath, dry mouth, nausea, vomiting, abdominal pain, or decreased appetite, tiredness, leg pain, or muscle weakness, agitation, irritability, nervousness, anxiety or excitability, rash or itching, feeling of intoxication, headache, and constipation.

  3. More common side effects may include:
    Abdominal pain, dizziness, drowsiness, intoxicated feeling, light-headedness, nausea, sedation, shortness of breath, vomiting

    Less common or rare side effects may include:
    Agitation, allergic reactions, constipation, depression, difficulty swallowing, dry mouth, earache, exaggerated feeling of well-being, excessive sweating, excessive urination, excitement, fainting, fatigue, fever, flatulence, headache, heartburn, heavy eyelids, high energy, hot spells, itching, leg pain, mental confusion, muscle fatigue, numbness, rapid heartbeat, ringing in the ears, seizure, shaky feeling, skin redness and/or peeling, sluggishness, stuffy nose, tingling

    Mental and physical dependence can occur with the use of barbiturates such as butalbital when these drugs are taken in higher than recommended doses over long periods of time

  4. According to the FDA, the following side effects have been noted:
    “drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, and intoxicated feeling.”

    Please look at the 13 page report below, which also provides information on the various sub-components and interactions with other drugs.

  5. Side effects

    Side effects for any drug are difficult to predict, but commonly reported side effects for Fioricet include:

    * Abdominal pain
    * Dizziness
    * Drowsiness
    * Intoxicated feeling
    * Light-headedness
    * Nausea
    * Sedation
    * Addiction


    Dangers and risks

    Fioricet contains acetaminophen, which has been shown to cause liver damage at higher dosages. Care should be excercised when using Fioricet to prevent possible liver damage. Fioricet also contains butalbital, which is an addictive, mind (and behavior) altering barbituate. Fioricet can be habit forming. Fioricet should not be mixed with alcohol, both due to the possibility of exacerbating liver damage in combination with the APAP, and due to increased risk of intoxication, respritory depression, and general sedation in combination with the butalbital.

  6. * drowsiness;
    * dizziness,, confusion or lightheadedness;
    * shortness of breath;
    * dry mouth;
    * nausea, vomiting, abdominal pain, or decreased appetite;
    * tiredness, leg pain, or muscle weakness;
    * agitation, irritability, nervousness, anxiety or excitability;
    * rash or itching;
    * feeling of intoxication;
    * headache; or
    * constipation.

    If you experience any of the following serious side effects, stop taking acetaminophen/butalbital/caffeine and seek emergency medical attention:

    * an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    * slow, weak breathing;
    * liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue);
    * blood problems (easy or unusual bleeding or bruising); or
    * low blood sugar (fatigue, increased hunger or thirst, dizziness, or fainting).

  7. Common Fioricet Side Effects
    When you take a new medication, common sense tells you that any new occurrences should be noted. With Fioricet, it is no different. Common side effects can include stomach cramping, bloating, feelings of dizziness, sleepiness, feeling light-headed, or even nausea.

  8. yes of curse but depends that what kind of pain killers ur taking.like they can hur your intestine and kidneys.

  9. Yes i have read that you will get addicted to Fioricet if you take it regularly i suggest you should tell your doctor to RX to something else i take Imitrex for migraines and its very good and you wont get addicted to it.

  10. Fioricet is butatlbital (a sedative ) along with acetaminophen ( Tylenol ) and caffeine. All medications have side effects- don’t forget that! This one can cause sedation, nausea, vomiting and many other garden-variety side effects. The big thing is that this drug can be habit forming- but under the close care of your doctor, you can use this drug safely. The one thing you need to be carefull of is that this drug contains acetaminophen- which is Tylenol- if you have a fever at some point and take Tylonol make sure you aren’t overdosing yourself. Also, long term daily use of acetaminophen can over time damage your liver. If you cont. to use this drug past 6 mos or so, you should perhaps ask your doctor about stitching to a different drug. Is this taken for Migrain? If so, there are lots of different drugs that can be used. Good luck!

  11. Like all controlled drugs it has a risk of dependency, if your physician per-scribed it twice daily then it is only to be taken when you are having an actual migraine not if you are just having certain symptoms. You can go to drugs.com and look up all the side effects and risks.

  12. I would look in a totally different direction to get relief.

    There is a one-time treatment Atlasprofilax that usually makes the migraine disappear – of course there is no guarantee.

    I have experienced the amazing effects myself… 🙂

    Now, the treatment is available in California and Europe only, costing approx. 220 dollars. And it’s worth to travel a far way to make the experience!